College football odds, picks, predictions for Aug. 27, 2022: Computer simulation fading Illinois in Week 0

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While most college football teams will see their first action of the year on Labor Day weekend, there are 11 games on the docket for Week 0 this Saturday. Nebraska will open its fifth season under head coach Scott Frost when it faces Northwestern in Ireland in a 12:30 p.m. ET kickoff. The Cornhuskers have yet to record a winning season since Frost’s arrival in 2018, and they will have plenty of new coaches on the sidelines following last year’s 3-9 campaign. Nebraska is an 11.5-point favorite in the latest Week 0 college football odds at Caesars Sportsbook.

The Cornhuskers will also have a new face under center after Adrian Martinez transferred to Kansas State during the offseason. Should you be backing new quarterback Casey Thompson with your Week 0 college football bets? Before finalizing any college football picks for Week 0 of the 2022 season, be sure to see the latest college football predictions from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also finished the 2021-22 college football season on a 43-31 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest college football odds for Saturday from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Aug. 27, 2022

One of the top college football picks the model is recommending for Saturday: Wyoming (+13) stays within the spread against Illinois in a 4 p.m. ET kickoff on Saturday in Champaign. The Cowboys capped off a winning 2021 campaign with a Potato Bowl victory over Kent State, while Illinois went 5-7 and missed a bowl game for the second consecutive year.

Wyoming lost its starting quarterback and first-string running back from last year’s team, but junior running back Titus Swen is ready to take over as the lead back. He rushed for 785 yards last season, averaging nearly six yards per touch. The Cowboys also have sophomore linebacker Easton Gibbs back as a defensive stopper after he recorded 90 tackles in 2021.

Illinois is going to lean heavily on its rushing attack in this game, as Syracuse transfer Tommy DeVito has gotten the starting nod and will likely need some time to settle in. A run-heavy attack also lends itself to a lower-scoring game, which is one reason why SportsLine’s model has the Cowboys covering the double-digit spread in 60% of simulations. See which other teams the model likes here.

How to make college football picks for Saturday, Aug. 27

The model has also made the call on who wins and covers in every other FBS matchup on Saturday, and it’s calling for a big favorite to get a huge scare. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which heavy favorite gets a big scare? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,600 in profit over the past six seasons, and find out.